Electron microscopy analysis of fibroblasts of SPG15 patients and neurons of Spg15 knockout mice showed the accumulation of zebra or fingerprint bodies (Khundadze et al., 2013; Renvoisé et al., 2014), which are lysosomes with accumulation of membranes similar to those found in some lysosomal storage disorders (Parkinson-Lawrence et al., 2010). Here, ZFYVE26 is linked to lysosomal storage disease.