In our study, we observed that CAP suppressed body mass gain in TRPV1 female KO mice, though this effect was greater in female WT mice, which is not consistent with the findings of Zhang et al. The first reason for this could be that male C57/BL6 mice are more vulnerable to HFD-induced obesity and metabolic syndrome compared with female C57/BL6 mice fed HFD (19, 20). This evidence concerns the gene TRPV1 and obesity due to melanocortin 4 receptor deficiency.