We also found a possible mechanism of CAP’s anti-obesity effect by enhancing PYY and GLP-1excretion in intestinal epithelial cells, which suppress NPY- and AgRP-expressing neurons and activate POMC- and CART-expressing neurons in the ARC of the hypothalamus, resulting in lower food intake. The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.