The down‐regulation of miR‐210‐3p expression could similarly increase the expression of EphrinA3, consistent with the fact that miR‐210‐3p inhibited tumour growth and metastasis.20 Taken together, the present study constructed an miR‐210‐3p‐EphrinA3‐PI3K/ATK signalling axis and highlighted that the knockdown of EphrinA3 expression may promote the development of EMT in tumour cells through the activation of PI3K/AKT pathway, thereby promoting tumour growth, invasion and metastasis and drug resistance. The gene discussed is AKT1; the disease is neoplasm.