In the PD study, our findings are 1) IFN-γ-induced TNFA and IL12 expression was similar and sensitive to FK506 in sPD and LRRK2 mutated groups, 2) IFN-γ-induced HLADRA1 expression was reduced in LRRK2 mutated group and was insensitive to FK506, and 3) IFN-γ-induced LRRK2 expression was unexpectedly increased in LRRK2-mutated group and was sensitive to FK506. This evidence concerns the gene HLA-DRA and Parkinson disease.