However, there are several different pathological proteins and aggregation morphologies in FTD, with generally weak correlations between clinical syndrome and the type of pathological protein (Seelaar et al., 2011) [with the exception of svPPA, which is strongly associated with TAR DNA-binding protein 43 (TDP-43) type C neuropathology] (Spinelli et al., 2017). The gene discussed is TARDBP; the disease is frontotemporal dementia.