Here we aim to build on recent in vivo studies of Alzheimer’s disease, which demonstrate that neuroinflammation correlates spatially with tau aggregation (Dani et al., 2018), by assessing whether this association extends to FTD, which is associated with many different conformations of pathological tau, or other protein aggregates such as TDP-43. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.