Elevated in vivo binding is seen in tauopathies characterized by straight filaments (Bevan-Jones et al., 2016; Passamonti et al., 2018; Smith et al., 2017; Jones et al., 2018), albeit with generally lower binding affinity than in Alzheimer’s disease, and also in TDP-43-related disease (Bevan-Jones et al., 2018a, 2018b; Makaretz et al., 2018). The gene discussed is TARDBP; the disease is tauopathy.