Therapeutic value of correcting the altered PI3K-Akt-S6K1 signaling in FXS is strongly suggested by that genetic removal/reduction of S6K1, PIKE, and p110ß subunit of PI3K can rescue the elevated overall protein synthesis and multiple behavioral abnormalities in Fmr1 KO mice18,28,35. The gene discussed is AKT1; the disease is fragile X syndrome.