Therapeutic value of correcting the altered PI3K-Akt-S6K1 signaling in FXS is strongly suggested by that genetic removal/reduction of S6K1, PIKE, and p110ß subunit of PI3K can rescue the elevated overall protein synthesis and multiple behavioral abnormalities in Fmr1 KO mice18,28,35. This evidence concerns the gene PIK3CD and fragile X syndrome.