Therapeutic value of correcting the altered PI3K-Akt-S6K1 signaling in FXS is strongly suggested by that genetic removal/reduction of S6K1, PIKE, and p110ß subunit of PI3K can rescue the elevated overall protein synthesis and multiple behavioral abnormalities in Fmr1 KO mice18,28,35. Here, FMR1 is linked to fragile X syndrome.