Furthermore, we compared RNFL thickness data of WS patients to a group of 70 healthy age and sex-matched controls and 16 DOA patients carrying Optic Atrophy 1 (OPA1) mutations (controls 32.1 ± 10.8, DOA 31.43 ± 14.1, WS 31.5 ± 12.7 years of age) (Fig. 1A,B). This evidence concerns the gene OPA1 and Werner syndrome.