Since KCNQ2-associated EE is an autosomal dominant epileptic syndrome, we repeated voltage-clamp recording in CHOhm1 cells transfected with plasmids for Kv7.3, wild-type Kv7.2, and mutant Kv7.2 at a 2:1:1 ratio as described35 (Fig. 5, Supplementary Figs. S6–7). The gene discussed is KCNQ2; the disease is ethylmalonic encephalopathy.