Among these proteins, neuronal KCNQ/Kv7 potassium (K+) channels have been implicated in epilepsy since mutations in the principle subunits, KCNQ2/Kv7.2 and KCNQ3/Kv7.3, cause Benign Familial Neonatal Epilepsy (BFNE [MIM: 121200]) and Epileptic Encephalopathy (EE [MIM: 613720]) (RIKEE database www.rikee.org). This evidence concerns the gene KCNQ3 and Epileptic encephalopathy.