As a main result we found that AGAT−/− mice exhibited altered gene expression related to energy metabolism (Fbp2, Ucp2), cardiac hypertrophy and fibrosis (Nppa, Ctgf), immune response (Fgl2), and the conduction system of the heart (Dsc2, Ehd4, Hcn2, Hcn4, Scn4a, Scn4b). Here, HCN4 is linked to cardiac hypertrophy.