Likewise, melatonin indirectly inhibits angiogenesis through the repression of IGF, EGF and ET-1 (tumor growth factors and enhancers of tumor angiogenesis)25 and diminishing the production of ROS, which has an important function in stabilizing hypoxia-inducible factor HIF-α during hypoxia26. The gene discussed is EGF; the disease is neoplasm.