Characteristic features of AML including splenomegaly and hepatomegaly were only observed in mice transplanted with ME-Transformed cells (Fig. 1g and Supplementary Fig. 1d), consistent with previous reports of bone marrow haematopoietic progenitor cells transduced with MLL-ENL as well as other MLL fusion genes5,18. Here, KMT2A is linked to Splenomegaly.