KMT2A and acute myeloid leukemia: However, MLL-ENL-mediated transcriptional dysregulation was readily captured in our model when ME-Parental cells were exposed to an adequate stimulus, for instance myeloid differentiation29, which allowed us to demonstrate that (i) gene expression changes during early myeloid differentiation correspond to immediate activation of the leukaemogenic program, and (ii) some of the transduced cells differentiated normally despite the expression of MLL-ENL, thus enhancing our broader understanding of the cellular permissiveness for AML development.