Figure 4g shows that MLL-ENL1 was particularly enriched for gene sets such as “Formation of translation preinitiation complex”, “DNA replication initiation” and “glycine metabolic process”25,40,41 which may be associated with the increase in cell cycle gene expression previously shown; and “positive regulation of telomerase activity”, previously reported as a promising target for AML cell eradication42. The gene discussed is KMT2A; the disease is acute myeloid leukemia.