First, we found that loss of one copy of Hmgn1 in Ts1Rhr progenitors (Ts1Rhr_HMGN1+/−; three copies of the 21q22 genes, except only two copies of Hmgn116) restored myeloid differentiation and that the differentiation block by AML-ETO9a was greater in Ts1Rhr compared to Ts1Rhr_HMGN1+/− cells (Fig. 5c). This evidence concerns the gene HMGN1 and acute myeloid leukemia.