Others, such as AML-ETO9a, MLL-AF9, PML-RARα, NRAS G12V, GATA2 R396W, NPM1mut (exon 12 insertion39), and MOZ-TIF2 cooperated with HMGN1 as seen by enhanced myeloid differentiation delay compared to either alteration alone (Fig. 5a, Supplementary Fig. 7a). Here, KMT2A is linked to acute myeloid leukemia.