EP300 and leukemia: We found that many targets of the HATs CBP and p300 in murine hematopoietic cells32 were upregulated in HMGN1-OE progenitors, including several genes important in HSCs and leukemia (e.g., HoxA and Hox B family, Meis1, and Msi2) (Fig. 3d; left, CBP targets; right, p300 targets).