We enriched CD117+ myeloid progenitors from 8-week-old wild-type or HMGN1-OE bone marrow and transduced the cells with a retrovirus expressing AML-ETO9a linked to GFP or with a GFP-only control, and then transplanted equivalent numbers of transduced cells into irradiated recipients (Fig. 5d). The gene discussed is KIT; the disease is acute myeloid leukemia.