Our result of relatively low TSPO availability in FEP does not support the notion of elevated TSPO expression as a marker of central inflammation in psychosis, and together with the earlier studies by Notter et al.16, Collste et al.83 and Plavén-Sigray et al.11, suggest that the onset of psychosis could be either unrelated to neuroinflammation or associated with low-grade neuroinflammation manifesting as lower second generation TSPO tracer VT. Here, TSPO is linked to psychotic disorder.