Further translational evaluation of these results by Coughlin et al., using a maternal immune activation mouse model of schizophrenia, suggested that there is no positive association of TSPO expression with central low-grade inflammation, and that downregulation of TSPO via non-immune mechanisms could predispose to low-grade inflammation via the reduction of the anti-inflammatory properties of TSPO16,91. Here, TSPO is linked to schizophrenia.