However, when Prdm3 was knocked out in pancreatic acinar cells, we observed that Prdm3 depletion potentiated pancreatic cancer initiation and progression to high-grade lesions including ductal carcinoma in situ, suggesting that Prdm3 plays a suppressive role in acinar-to-ductal transformation. The gene discussed is MECOM; the disease is pancreatic neoplasm.