These are associated with a number of conditions including heart disease, diabetes, cancer81 and—in the case of CRP—even depression.82, Table 5 shows that both biomarkers have rising morbidity from 1997 to 2000 to 2008–2010 (although for CRP, the CI is wide and there is a non-negligible possibility that the change is negative). This evidence concerns the gene CRP and major depressive disorder.