Previous studies have shown that Rag1−/− and Sh2b3−/− (Sh2b3 plays a suppressive role in the activation of immune responses and cytokine signaling) SS rats were protected from hypertension after having been fed a high-salt diet (Mattson et al., 2013; Rudemiller et al., 2015). Here, SH2B3 is linked to Hypertension.