Several studies have shown that SGK1 is crucial for regulating IL-23R expression and stabilizing the pathogenic Th17 cell phenotype by phosphorylation and cytosolic translocation of FOXO1, a direct repressor of IL-23R expression in high-salt-induced inflammation and angiotensin II-induced hypertension (Kleinewietfeld et al., 2013; Wu et al., 2018). This evidence concerns the gene AGT and hypertensive disorder.