We found that basophils are the major source of Il4 mRNA in our mouse model of acute AD, as evidenced by RT quantitative PCR analysis of sorted skin cells (unpublished observations), which likely explains the normal upregulation of Il4 expression and the IL-4 downstream target Ccl2440 in ovalbumin-sensitized skin of acutely sensitized Il17rb–/– mice. The gene discussed is IL4; the disease is Alzheimer disease.