Among the best-performing signatures, BATF2, Kaforou25, and Roe3 were originally discovered by comparing patients with active tuberculosis with asymptomatic individuals.13, 27, 31 Nonetheless, their performance in this observational cohort of almost exclusively symptomatic patients suggests that these signatures can discriminate between tuberculosis and the casemix of other symptomatic illness in this context. The gene discussed is BATF2; the disease is tuberculosis.