APOA1 and Autoimmunity: Furthermore, autoantibodies to apoA-1 and HDL-C have been reported in patients with other autoimmune conditions such as systemic lupus erythematosus, rheumatoid arthritis and antiphospholipid syndrome with reported higher cardiovascular risk and may therefore represent another mechanism potentially leading to proinflammatory properties of apoA-1/HDL-C [34].