Wallace et al. demonstrated the effect of high LDL-C on the incidence coronary disease, by demonstrating an association between serum LDL-C levels and single-nucleotide polymorphisms (SNPs) in gene variants of the Proline/serine-rich coiled-coil protein 1 (PSRC1) and Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) [52]. The gene discussed is PSRC1; the disease is coronary artery disorder.