WNK2 and open-angle glaucoma: For the GO analysis, POAG was significantly enriched in ubiquitin-like protein ligase binding, ubiquitin protein ligase binding, transcription factor activity, etc. The KEGG-enriched analysis results indicated that major pathways, including the mitogen-activated protein kinase (MAPK) signaling pathway, endocytosis pathway, and Wnt signaling pathway, were involved in these mRNAs.