In summary, during this study, a POAG-related lncRNA–miRNA–mRNA ceRNA network was constructed, and hub lncRNAs, such as OIP5-AS1, DNAJC27-AS1, AF121898, and SNX29P2, were identified in the development of POAG, which provided novel insights into exploring the underlying mechanism of POAG. This evidence concerns the gene DNAJC27 and open-angle glaucoma.