OIP5 and open-angle glaucoma: In summary, during this study, a POAG-related lncRNA–miRNA–mRNA ceRNA network was constructed, and hub lncRNAs, such as OIP5-AS1, DNAJC27-AS1, AF121898, and SNX29P2, were identified in the development of POAG, which provided novel insights into exploring the underlying mechanism of POAG.