The MCM family (MCMs) has been reported to be associated with numerous cancer types [35,36,37], such as the promotion of metastasis of liver cancer through the Mitogen-activated protein kinase kinase(MEK)/ extracellular signal-regulated kinases (ERK) pathway (MCM6) [38], as a prognostic factor in patients with lung squamous cell carcinoma [39]. Here, MAP2K7 is linked to liver cancer.