The mechanobiology of oxidative stress-related genes (i.e., catalase; superoxide dismutase 1, SOD1; and glutathione peroxidase 1, GPx-1) upon exposure to pure AgNPs in human hepatoma cells has been studied; these genes have been found to be implicated in maintaining antioxidant defense capacity [39]. The gene discussed is SOD1; the disease is hepatocellular carcinoma.