Consistent with previous reports [276], the levels of cytoplasmic APC in colorectal tumor cells harboring an APC mutation (SW480, SW620, HT29, Caco-2 and LoVo cells) were significantly higher than those in MDCK II and colorectal tumor cells with wild-type APC (HCT116 and SW48 cells). The gene discussed is APC; the disease is colorectal neoplasm.