MYC and cancer: In cancer, the miRNA expression is abnormal due to amplification, deletion, translocation, or epigenetic silencing of miRNA genes; the dysregulation of transcription factors (e.g., p53 and c-Myc); and defects in the biogenesis enzymatic equipment (e.g., point substitutions/deletions of DGCR8 or DROSHA, mutations of XPO5—exportin encoding gene, and Dicer dysregulations) [17].