Regardless of plant species or plant tissues, the activation of the plant defense signaling including oxidative stress (e.g., Reactive oxygen species (ROS) response) and the up-regulation of pathogenesis-related genes (e.g., PR-1) is frequently observed during BNYVV infection [7,11,12], indicating a shared response to BNYVV infection aong phylogenetically-distant plant species. This evidence concerns the gene TMEM37 and infection.