The production of adipocytokines including adiponectin, irisin, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), leptin, interleukin-6 (IL-6) are found to be deregulated in MetS due to the oxidative stress situation [16,17]. The gene discussed is TNF; the disease is metabolic syndrome.