PTEN and Familial prostate cancer: In particular, microarray analysis in prostate cancer cells, LNCaP and DU145 cells, has revealed that RES either reduces or increases the levels of many miRNAs associated with prostate tumor; the main oncomiRNAs, negatively modulated by RES, commonly inhibit the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a tumor suppressor that is down-regulated in several types of cancer [120].