Curcumin, in an in vitro study on murine prostate cancer cells, elicited demethylation of the promoter of Nrf2 gene, a master regulator of detoxifying/antioxidant enzymes, leading to the re-expression of Nrf2 and NAD(P)H dehydrogenase, and quinine-1(NQO-1), key players in the antioxidant and stress responses [122]. This evidence concerns the gene NFE2L2 and Familial prostate cancer.