Moreover, SE-IgE was associated with asthma (OR 2.10, 95% CI 1.60–2.76, p = 0.001) in a serum concentration-dependent manner (OR 1.20, 1.74, 2.57 for the first, second, and third tertile, respectively, above 0.10 kUA/L; kilounits of allergen-specific IgE per liter) independent of the SPT results for inhalant allergens. The gene discussed is IGHE; the disease is asthma.