IGHE and asthma: Logistic regression analyses demonstrated significantly increased risks for SE-IgE positive subjects compared to negative subjects to have any asthma (OR 7.25, 95% CI 2.7–19.1; p < 0.001) or severe asthma (OR 11.09, 95% CI 4.1–29.6; p < 0.001) [67], whereas grass pollen- or house dust mite-specific IgE was not associated with any risk.