In a meta-analysis of 10 studies, patients with asthma (OR 3.3, 95% CI: 1.6–7.1, p = 0.002) and allergic rhinitis (OR 2.4, 95% CI: 1.3–4.7, p = 0.008) were significantly more likely than controls to be SE-IgE positive [86]. The gene discussed is IGHE; the disease is allergic rhinitis.