VEGFA and melanoma: It was detected that there were decreased MMP-1, MMP-2 and MMP-9 in the mitochondria, as well as downregulation of the NF-κB pathway, AKt pathway, FAK, p-EGFR, p-JNK and Rho A. Casticin increased the expression of certain genes, including cell adhesion molecule 1 (SCN1B), and decreased the expression of vascular endothelial growth factor A (VEGFA), which are associated with cell invasion and migration in mouse melanoma cell lines.