It has been found that various concentrations of casticin can reverse the EMT process by increasing E-cadherin expression while inhibiting N-cadherin in oral squamous cell carcinoma (OSCC) UM1 cells [99], ovarian cancer SKOV3 cells [103] and liver cancer stem cells (LCSCs) derived from the SMMC-7721 cells [79]. The gene discussed is CDH2; the disease is ovarian cancer.