We demonstrated through the use of a combination of in vitro assays that 1) only the delivery of miRNA combinations instead of single miRNAs via nanoparticles is able to achieve a growth inhibitory effect in a variety of BRAF-mutated melanoma cell lines; 2) dual miRNA-loaded LNPs are able to potentiate the growth inhibitory effect of target therapy. This evidence concerns the gene BRAF and melanoma.