CD40LG and neoplasm: In situ vaccination is an alternative way to exploit the potentiality of DCs for priming tumor-specific T cell activation, that is, the intratumoral inoculation of DC activators/adjuvants, such as TLR agonists [29,55,56] or CD40L [57] to stimulate DCs to uptake and process TAAs and specific neo-antigens directly released from tumor cells in the surrounding TME [58].