ENAM and dental caries: Likewise, in our study we found that this gene may predict the developing of these lesions, such as that reported in other studies where the presence of the ENAM variant rs12640848 in the population may predict the development of caries; this finding is consistent with the study made by Gerreth et al., which reported the association of the ENAM gene and the susceptibility to caries in primary teeth in children [25], as well as that reported by Devang et al., which found a significant association between other variants of the ENAM variant rs7671281, and susceptibility to dental caries [26].