Moreover, the insulin dosage before pregnancy by placental weight ratio in the T1DM+HDP group was higher than that in the T2DM group (p = 0.0002 against that in the T2DM+HDP group, p = 0.0007 against that in the T2DM alone group, and p = 0.0059 against that in the T2DM+CH group; see Fig 3B). This evidence concerns the gene INS and type 2 diabetes mellitus.