The presence and the distribution of various polymorphisms associated with the surface antigens of the erythrocytes, including the globin genes (HbS, HbC, HbE) Thalassemias, oxidative stress (G6PD), cytoadherence and the immune system have been associated with a certain level of a protective effect against malaria [28]. The gene discussed is KRT88P; the disease is thalassemia.