Two missense variants with a MAF of 0.0016% and 0.0012% were identified in known disease genes (S1 Table): c.889C>T/p.(Arg297Cys) in DHX38 (MIM: 605584) in which two other amino acid substitutions have been reported in individuals with autosomal recessively inherited early-onset retinitis pigmentosa (MIM: 268000) [52, 53] and c.5083C>A/p.(Pro1695Thr) in MYO15A (MIM: 602666) in which biallelic mutations cause autosomal-recessive, nonsyndromic deafness (DFNB3, MIM: 600316) [54, 55]. The gene discussed is DHX38; the disease is hearing loss, autosomal recessive.