Finally, compound heterozygous mutations in the CACNA1A gene encoding the pore-forming α1A subunit of the CaV2.1 voltage-gated calcium channel have been reported to cause epileptic encephalopathy with progressive cerebral atrophy, optic nerve atrophy, hypotonia, and severe developmental delay [92]. Here, CACNA1A is linked to Epileptic encephalopathy.