In short‐term preclinical models of sepsis, ghrelin has been shown to decrease pro‐inflammatory cytokine levels, stimulate proliferation of T cells, and attenuate the decrease in serum levels of IGF‐1 (Faim et al, 2019); however, we found that ghrelin infusion in a long‐term rodent fecal peritonitis model had no impact on outcomes (Hill et al, 2017). This evidence concerns the gene GHRL and Sepsis.