There may be no magic target to cure sepsis, and a combined approach could be more beneficial than targeting a single molecule, as shown for IL‐1 and IL‐18 in murine sepsis (Vanden Berghe et al, 2014), IL‐1 and TNF in a rat model (Russel et al1995), or CD14 and factor XIa in rabbits (Nakamura et al, 2017). Here, TNF is linked to Sepsis.