Winkler et al found that m6A can act as a negative regulator of the type I IFN response by controlling IFNA and IFNB mRNA expression.23 IFNs stimulate the JAK/STAT pathway and activate the expression of hundreds of inactivated genes (ISGs) against viral infections.23 The conflicting effects of type I IFN signalling on immune responses are well recognized. This evidence concerns the gene IFNB1 and viral infectious disease.