Atherosclerosis in coronary arteries is critical to the pathogenesis of CAD.[17] Inflammation plays a key role in atherosclerosis and VitD deficiency is a known cause of inflammation.[18,19] Low VitD levels directly increase C-reactive protein (CRP) synthesis and the protective effects of VitD to CRP are evidenced by the distribution of VitD receptors in the vascular walls.[20] In vivo studies have shown that a loss of VitD receptor expression influences cardiac function. The gene discussed is CRP; the disease is atherosclerosis.