TNF and acute liver failure: Hepatocyte apoptosis induced by death receptor ligands (DRLs) such as tumor necrosis factor-α or Fas is known to have an important role in various liver diseases, including alcoholic hepatitis, viral and inflammatory hepatitis, acute liver failure, and ischemia/reperfusion injury.[25,26] Recent studies have demonstrated that T3 has an anti-apoptotic effect by affecting different molecular pathways on hepatocytes.