It has the effects of sodium and diuretics, reducing vascular tone and antagonizing the renin-angiotensin-aldosterone (Ald) system and sympathetic nervous system activity.[5] Lyophilized recombinant human brain natriuretic peptide (rhBNP) can mimic the action of endogenous brain natriuretic peptide, and its clinical application in HF has become the central focus of research.[6]. This evidence concerns the gene NPPB and hydrops fetalis.