UGT2B15 and polycystic ovary syndrome: It is now well established that UGT2B7, UGT2B15, and UGT2B17 are the 3 major enzymes responsible for the glucuronidation of all androgen and their metabolites in humans.[30] Our results suggested that patients with PCOS had higher T and FT concentrations than those in the control group, which could be explained by the following 2 potential causes: firstly, the TT mutation of UGT2B7H268Y decreased the clearance of androgen in PCOS; secondly, although the TT mutation of UGT2B15D85Y promoted the excretion of androgen, the TT mutation frequency was much lower in patients with PCOS.