On this basis, we attempted to make further step by investigating the potential role of TAP in other cancers, for example, liver, pancreatic, gallbladder, and bile duct, which to our knowledge have not been clarified; the performance of TAP compared with other established cancer marker, such as alpha fetoprotein (AFP), and carbohydrate antigen 19-9 (CA19-9); the potential of combining TAP with other marker in cancer prognosis. The gene discussed is AFP; the disease is cancer.