AFP and cancer: Interestingly, the analysis of public TCGA data set showed that high expression of AFP resulted in the significant decrease of cumulative survival among patients with LIHC and KIRC; however, completely opposite change was found in SARC that high expression of AFP caused enhanced cumulative survival, revealing the limitation of AFP that it was only specific to selected (e.g., liver, renal) but not other cancers (e.g., sarcoma).