KPNA2 was identified as a potential biomarker for non-small-cell lung cancer (NSCLC) by integration of the cancer cell secretome and tissue transcriptome.[53] Xiaolei's study provided direct evidence to demonstrates that KPNA2 may contribute to nuclear translocation in lung cancer.[54] So far, we have not found any research and reports on the GPR137C gene, which may become an innovation and hot spot for future research. The gene discussed is KPNA2; the disease is non-small cell lung carcinoma.