At the same time, we found that the DE-genes (RBMS3, NEDD9, CRIM1, KPNA2, GPR137C, and GRIK3), hsa-miR-7–5p, hsa-miR-18a-5p, hsa-miR-144–3p, hsa-miR-1–3p, and the protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development are highly likely to be related to the SCLC. This evidence concerns the gene RBMS3 and small cell lung carcinoma.