In conclusion, we have successfully identified differential expression of genes (RBMS3, NEDD9, CRIM1, TGFBR2, MYO1C, KLF4, EMP2, TMEM2, CTGF, TNFAIP3, THBS1, KPNA2, GPR137C, GRIK3, and MTHFD2) and upstream miRNAs (hsa-miR-7–5p, hsa-miR-18a-5p, hsa-miR-18a-5p, hsa-miR-9–5p, hsa-miR-9–5p, hsa-miR-7–5p, hsa-miR-1290, hsa-miR-18a-5p, hsa-miR-18a-5p, hsa-miR-18a-5p, hsa-miR-182–5p, hsa-miR-144–3p, hsa-miR-1–3p, hsa-miR-144–3p, and hsa-miR-30a-3p) in SCLC based on bioinformatic analysis. Here, MTHFD2 is linked to small cell lung carcinoma.