NF-κB p65 is necessary for initiation of the inflammatory response in response to LPS (McDonald et al., 1997; Hobbs et al., 2018), for the development of Th17 cells via induction of the transcription factor RORγ (Ruan et al., 2011a), and for pathology in many diseases with inflammatory components, including inflammatory bowel disease (Han et al., 2018; Schreiber et al., 1998) and dry eye syndrome (Tan et al., 2018; He et al., 2011). This evidence concerns the gene NFKB1 and inflammatory bowel disease.