DNER and cancer: Recent studies from several groups have identified that BRD4 regulates cancer cell dissemination through upregulation of stem cell signaling, Jagged1/Notch and ALDH1A activity, while BET inhibition suppressed Jagged1/Notch signaling and ALDH1 activity by targeting Jagged1 promoter or ALDH1A1 superenhancer in breast or ovarian cancers (Andrieu et al., 2016; Yokoyama et al., 2016).