It is involved in multiple interactions such as oxidative stress, inflammation, and regulation of pain‐related key molecule 6, 7, 8 and plays an important role in chronic complications of diabetes.9, 10 Our previous study reported that NF‐κB specifically bound to the P2X3 promoter region and promoted P2X3 receptor expression, contributing to diabetic neuropathic pain.8 At present, it has not been reported whether NF‐κB could regulate TRPV1 expression. The gene discussed is P2RX3; the disease is diabetes mellitus.