TRPV1 and diabetes mellitus: It is involved in multiple interactions such as oxidative stress, inflammation, and regulation of pain‐related key molecule 6, 7, 8 and plays an important role in chronic complications of diabetes.9, 10 Our previous study reported that NF‐κB specifically bound to the P2X3 promoter region and promoted P2X3 receptor expression, contributing to diabetic neuropathic pain.8 At present, it has not been reported whether NF‐κB could regulate TRPV1 expression.