For example, TRPV1 and purinergic P2X receptor played important roles in diabetes‐induced pain sensitivity, through increasing current density and enhancing signal transmission.8, 25 Recently, we reported that ALA could reduce the expression and function of P2X3 in DRG neurons from diabetic rats.18 Actually, TRPV1 is also a representative ligand‐gated channel that plays a role in diabetic neuropathic pain. The gene discussed is P2RX3; the disease is diabetes mellitus.