In assessing association of this variant with cancer, of the 15 679 BRCA1 carriers, 7889 and 2369 carriers were affected with breast and ovarian cancers, respectively; of 10 979 BRCA2 carriers, 5605 carriers and 2369 carriers were diagnosed with breast and ovarian cancers, respectively. The gene discussed is BRCA2; the disease is ovarian carcinoma.