In Oncomine database, KPNB1 (P < 0.001) was significantly differentially expressed between ACC and normal adrenal tissue, H2AFX (median rank 3.0, COPA = 11.927) and SGPL1 (median rank 2301.0, COPA = 4.230) were abnormal up-regulated in ACC in the outlier analysis across multiple studies (Supplementary Figure S4). This evidence concerns the gene KPNB1 and adrenal cortex carcinoma.