Mechanistically, overexpression of GDNF in transgenic mice reduced the expression of master regulators of lipid homeostasis, including sterol regulatory element binding transcription factor 1 (SREBF1), PPARα, PPARγ, and carnitine palmitoyltransferase 1 (CPT1), all of which are elevated in models of NAFLD. Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.